Formulasi dan Uji Aktivitas Antibakteri Nanoemulsi Mouthwash Ekstrak Etanol Daun Jeringau (Acorus calamus Linn.)

نویسندگان

چکیده

Ekstrak daun jeringau telah diketahui mengandung flavonoid dan saponin serta berkhasiat antibakteri. Potensi tersebut dapat dikembangkan menjadi sediaan farmasi yang lebih praktis yaitu nanoemulsi mouthwash. Tujuan penelitian ini adalah memformulasikan komponen uji aktivitas antibakteri pada formula baik. Nanoemulsi dibuat menggunakan variasi IPM:Tween 80:Propilenglikol dengan perbandingan F1 (1:8:1); F2 (2,15:5,7:2,15); F3 (3,25:5,2:1,55). Pengujian organoleptis, sentrifugasi, transmitan, pH, viskositas, bobot jenis. Formula terbaik dilanjutkan pengujian ukuran partikel, zeta potensial metode disc diffusion. organoleptis 3 stabil selama 7 hari tetap jernih tidak mengalami pemisahan fase, sedangkan terjadi creaming. Uji transmitan F1-3 96,8%+0,00; 95,9%+0,00; 96,73+0,06. pH 5,92+0,02; 5,89+0,01; 5,92+0,01. Viskositas 1,681 Cps +0,02; 1,460 +0,01; 1,533 Cps+0,03. Bobot jenis sebesar 1,030 g/mL; 1,026 1,026+ g/mL. dipilih sebagai baik, hasil partikel 239,97+ 3,45 nm -30,5+1,11 mV. mouthwash ekstrak etanol 1% memiliki terhadap Streptococcus mutans diameter daya hambat 30,33+0,58 mm hampir sama Clindamysin kontrol positif 33+1,00 mm.

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ژورنال

عنوان ژورنال: Jurnal Sains dan Kesehatan

سال: 2022

ISSN: ['2303-0267', '2407-6082']

DOI: https://doi.org/10.25026/jsk.v4ise-1.1694